Publications

G-CAN Publications

• Review: Metabolic Impact of XOR Inhibitors Use and Discontinuation
  by Mai Sekine and Kimiyoshi Ichida
  Gout Urate Cryst. Depos. Dis. 2025, 3(2), 9; DOI: 10.3390/gucdd3020009
• Review: Comparison of Pathophysiological Mechanisms Among Crystal-Induced Arthropathies
  by Maddalena Zangari, Roberto Luisetto, Roberto Pilot, Paola Contessa, Raffaella Signorini, Stefano Masiero and Anna Scan
  Gout Urate Cryst. Depos. Dis. 2025, 3(2), 7; DOI: 10.3390/gucdd3020007
• Review: Mendelian Randomization Studies: A Metric for Quality Evaluation
  by Fiorella Rosas-Chavez and Tony R. Merriman
  Gout Urate Cryst. Depos. Dis. 2025, 3(2), 8; DOI: 10.3390/gucdd3020008
• Article: Higher Rates of Psoriatic Arthritis in Patients with Calcium Pyrophosphate Deposition Disease than in Controls: A Retrospective Cohort Study 
  by Natalie Anumolu, Ann Rosenthal, Katherine Sherman and Shikha Singla
  Gout Urate Cryst. Depos. Dis. 2025, 3(2), 5; DOI: 10.3390/gucdd3020005
• Article: Colocalization Analysis Reveals Shared Genetic Loci Contributing to Gout and Metabolite Levels
  by Riku Takei, Nicholas A. Sumpter, Megan P. Leask and Tony R. Merriman
  Gout Urate Cryst. Depos. Dis. 2025, 3(2), 6; DOI: 10.3390/gucdd3020006
• Conference Report: Gout, Hyperuricemia and Crystal-Associated Disease Network (G-CAN) Conference 2024: Early-Career Investigators’ Abstracts
  by Gout and Hyperuricemia and Crystal–Associated Disease Network
  Gout Urate Cryst. Depos. Dis. 2025, 3(2), 10; DOI: 10.3390/gucdd3020010
• Review: Gout in China 
  by Aichang Ji, Zibin Tian, Yongyong Shi, Riku Takei, Shun-Jen Chang, Ronald M. L. Yip, Huiyong Yin and Changgui Li 
  Gout Urate Cryst. Depos. Dis. 2025, 3(1), 1; DOI: 10.3390/gucdd3010001
• Review: Convergence of Psoriatic Arthritis and Hyperuricemia: A Review of Emerging Data from This New Concept Called “Psout”
  by Renaud Felten, Laura Widawski, Pierre-Marie Duret, Lionel Spielmann and Laurrent Messer
  Gout Urate Cryst. Depos. Dis. 2025, 3(1), 4; DOI: 10.3390/gucdd3010004
• Perspective: Can Urate Lowering Therapy Be Stopped in Gout? Rationale and Design of Two Large Randomised Trials 
  by Pascal Richette, Marcel Flendrie, Leo A. B. Joosten and Noortje van Herwaarden
  Gout Urate Cryst. Depos. Dis. 2025, 3(1), 2; DOI: 10.3390/gucdd3010002
• Perspective: Treat to Target in Gout Management: A Critical Reappraisal of Current Strategies 
  by Anusha Moses, Martijn Oude Voshaar, Mart van de Laar and Tim L. Th. Jansen
  Gout Urate Cryst. Depos. Dis. 2025, 3(1), 3; DOI: 10.3390/gucdd3010003
• Review: Epigenomic Reprogramming in Gout
  by Ancuta R. Straton, Brenda Kischkel, Tania O. Crișan and Leo A. B. Joosten
  Gout Urate Cryst. Depos. Dis. 2024, 2(4), 325-338; DOI: 10.3390/gucdd2040023
• Review: Year in Review 2023: Gout Clinical Research
  by Greg Challener and Chio Yokose
  Gout Urate Cryst. Depos. Dis. 2024, 2(4), 354-369; DOI: 10.3390/gucdd2040025
• Article:A Novel Polarized Light Microscope for the Examination of Birefringent Crystals in Synovial Fluid
  by John D. FitzGerald, Chesca Barrios, Tairan Liu, Ann Rosenthal, Geraldine M. McCarthy, Lillian Chen, Bijie Bai, Guangdong Ma and Aydogan Ozcan
  Gout Urate Cryst. Depos. Dis. 2024, 2(4), 315-324; DOI: 10.3390/gucdd2040022
• Article:Assessing Changes in Vascular Inflammation and Urate Deposition in the Vasculature of Gout Patients After Administration of Pegloticase Using Positron Emission Tomography and Dual-Energy Computed Tomography—A Pilot Study 
  by Ira Khanna, Venkatesh Mani, Renata Pyzik, Audrey Kaufman, Weiwei Chi, Emilia Bagiella, Philip Robson and Yousaf Ali
  Gout Urate Cryst. Depos. Dis. 2024, 2(4), 339-353; DOI: 10.3390/gucdd2040024
• Article: Age-Associated Calcification: Insights from Murine Models
  by Sonia Nasi, Mario Romani and Nathalie Busso
  Gout Urate Cryst. Depos. Dis. 2024, 2(3), 236-251; https://doi.org/10.3390/gucdd2030018 – 2 August 2024
• Conference Report: Gout, Hyperuricemia and Crystal-Associated Disease Network (G-CAN) Conference 2023: Early-Career Investigators’ Abstracts
  by Gout, Hyperuricemia and Crystal-Associated Disease Network
  Gout Urate Cryst. Depos. Dis. 2024, 2(2), 173-205; https://doi.org/10.3390/gucdd2020015 – 6 Jun 2024
• Article: SGLT2 Inhibitors and Uric Acid Homeostasis
  by Ava M. Zapf and Owen M. Woodward
  Gout Urate Cryst. Depos. Dis. 2024, 2(2), 157-172; https://doi.org/10.3390/gucdd2020014 – 31 May 2024
• Article: Gout and Gout-Related Comorbidities: Insight and Limitations from Population-Based Registers in Sweden
  
  by Panagiota Drivelegka,Lennart TH Jacobsson and Mats Dehlin
  Gout Urate Cryst. Depos. Dis. 2024, 2(2), 144-156; https://doi.org/10.3390/gucdd2020013 – 7 May 2024
• Article: Circadian Rhythms in NLRP3 Inflammasome Regulation: Possible Implications for the Nighttime Risk of Gout Flares
  by Raewyn C. Poulsen andNicola Dalbeth
  Gout Urate Cryst. Depos. Dis. 2024, 2(2), 108-132; https://doi.org/10.3390/gucdd2020011 – 15 Apr 2024
• Article: Sex-Specific Differences in Cytokine Production Capacity in Patients with Gout Compared to Controls
  by Medeea Badii,Orsolya I. Gaal,Ioana Hotea,Valentin Nica,Andreea M. Mirea,Dragoş Mărginean,HINT Consortium,Cristina Pamfil,Simona Rednic,Radu A. Popp,Tania O. Crişan andLeo A. B. Joosten
  Gout Urate Cryst. Depos. Dis. 2024, 2(2), 133-143; https://doi.org/10.3390/gucdd2020012 – 22 Apr 2024
• Review: Calcium Pyrophosphate and Basic Calcium Phosphate Crystal Arthritis: 2023 in Review 
  by Augustin Latourte,Hang-Korng Ea andPascal Richette
  Gout Urate Cryst. Depos. Dis. 2024, 2(2), 101-107; https://doi.org/10.3390/gucdd2020010 – 5 Apr 2024
• Article: Optimising the Use of Ultrasound in Gout: A Review from the Ground Up 
  by Emilio Filippucci,Edoardo Cipolletta,Silvia Sirotti andGeorgios Filippou
  Gout Urate Cryst. Depos. Dis. 2024, 2(2), 86-100; https://doi.org/10.3390/gucdd2020009 – 4 Apr 2024
• Article: Prevalence and Influence of Gout in Patients with Advanced Chronic Kidney Disease: Findings of a Large Retrospective Chart Review 
  by Leonard Stern,Richard J. Johnson,Payam Shakouri,Amod Athavale,Lissa Padnick-Silver,Brian LaMoreaux,Brad A. Marder andSreedhar Mandayam
  Gout Urate Cryst. Depos. Dis. 2024, 2(1), 77-85; https://doi.org/10.3390/gucdd2010008 – 21 Mar 2024
• Article: Serum Urate as a Surrogate Outcome for Gout Flares: Where Do We Stand Today?
  by Lisa K. Stamp,Robin Christensen andMelanie B. Morillon
  Gout Urate Cryst. Depos. Dis. 2024, 2(1), 70-76; https://doi.org/10.3390/gucdd2010007 – 11 Mar 2024
• Review: The Evolving Landscape of Gout in the Female: A Narrative Review
  Jennifer Lee, Nicholas Sumpter, Tony R. Merriman, Ru Liu-Bryan and Robert Terkeltaub
  Gout Urate Cryst. Depos. Dis. 2024, 2(1), 1-16; DOI: 10.3390/gucdd2010001 
• Review: Imaging Follow-Up of MSU Crystal Depletion
  Sébastien Ottaviani
  Gout Urate Cryst. Depos. Dis. 2024, 2(1), 34-44; DOI: 10.3390/gucdd2010003
• Review: A New Era for Calcium Pyrophosphate Deposition Disease Research: The First-Ever Calcium Pyrophosphate Deposition Disease Classification Criteria and Considerations for Measuring Outcomes in Calcium Pyrophosphate Deposition Disease
  Sara K. Tedeschi
  Gout Urate Cryst. Depos. Dis. 2024, 2(1), 52-59; DOI: 10.3390/gucdd2010005
• Review: Serum Urate as a Surrogate Outcome for Gout Flares: Where Do We Stand Today?
  Lisa K. Stamp, Robin Christensen and Melanie B. Morillon
  Gout Urate Cryst. Depos. Dis. 2024, 2(1), 70-76; DOI: 10.3390/gucdd2010007
• Article: Prevalence and Influence of Gout in Patients with Advanced Chronic Kidney Disease: Findings of a Large Retrospective Chart Review
  Leonard Stern, Richard J. Johnson, Payam Shakouri, Amod Athavale, Lissa Padnick-Silver, Brian LaMoreaux, Brad A. Marder and Sreedhar Mandayam
  Gout Urate Cryst. Depos. Dis. 2024, 2(1), 77-85; DOI: 10.3390/gucdd2010008
• Technical Note: Optimizing the Use of Ultrasound in Calcium Pyrophosphate Deposition (CPPD): A Review from the Ground Up
  Georgios Filippou, Silvia Sirotti, Edoardo Cipolletta and Emilio Filippucci
  Gout Urate Cryst. Depos. Dis. 2024, 2(1), 17-33; DOI: 10.3390/gucdd2010002
• Brief Report: The Prevalence of Titanium Dioxide Particles in Synovial Fluid Samples Drops after European Union Ban
  Tom Niessink, Matthijs Janssen, Tim L. Jansen and Cees Otto
  Gout Urate Cryst. Depos. Dis. 2024, 2(1), 45-51; DOI: 10.3390/gucdd2010004
• Conference Report: 14th European Crystal Network (ECN) Workshop—Abstract Proceedings
  Frédéric Lioté, Fernando Perez-Ruiz, Hang-Korng Ea, Tony Merriman, Tristan Pascart and Alexander So
  Gout Urate Cryst. Depos. Dis. 2024, 2(1), 60-69; DOI: 10.3390/gucdd2010006
• Review: Gout in Paleopathology: A Review with Some Etiological ConsiderationsNellissa Y. Ling, Siân E. Halcrow and Hallie R. Buckley. Gout Urate Cryst. Depos. Dis. 2023, 1(4), 217-233; DOI: 10.3390/gucdd1040018
• Review: Calcium Pyrophosphate and Basic Calcium Phosphate Deposition Diseases: The Year in Review 2022
  Geraldine Mary McCarthy. Gout Urate Cryst. Depos. Dis. 2023, 1(4), 234-242; DOI: 10.3390/gucdd1040019 
• Pascart, T., Budzik, J. Does Monosodium Urate Crystal Vascular Deposition Exist? Review of the Evidence. Gout Urate Cryst. Depos. Dis.2023, 1(3), 208-216; https://doi.org/10.3390/gucdd1030017– 11 Sep 2023.
• Liu-Bryan, R., Guo, T., Lee, J., Terkeltaub, R. Atherogenic Activation of Human Vascular Smooth Muscle Cells by Monosodium Urate Crystals. Gout Urate Cryst. Dis.2023, 1(3), 192-207; https://doi.org/10.3390/gucdd1030016– 14 Aug 2023.
• Gout, Hyperuricemia and Crystal-Associated Disease Network. Gout, Hyperuricemia and Crystal-Associated Disease Network (G-CAN) Conference 2022: Early-Career Investigators’ Abstracts. Gout Urate Cryst. Depos. Dis.2023, 1(3), 167-191; https://doi.org/10.3390/gucdd1030015 – 03 Aug 2023.
  Andrés, M. Gout and Cardiovascular Disease: Mechanisms, Risk Estimations, and the Impact of Therapies. Gout Urate Cryst. Depos. Dis.2023, 1(3), 152-166; https://doi.org/10.3390/gucdd1030014– 01 Aug 2023.
  Cobo, I., Murillo-Saich, J., Alishala, M., Guma, M. Epigenetic and Metabolic Regulation of Macrophages during Gout. Gout Urate Cryst. Depos. Dis.2023, 1(3), 137-151; https://doi.org/10.3390/gucdd1030013 – 12 Jul 2023.
  Elsaid, K., Jay, G. Liu-Bryan, R., Terkeltaub, R. Proteoglycan 4 (PRG4)/Lubricin and the Extracellular Matrix in Gout. Gout Urate Cryst. Depos. Dis.2023, 1(3), 122-136; https://doi.org/10.3390/gucdd1030012– 11 Jul 2023.
  King, R., Kelley, E.. Urate Biology and Biochemistry: A Year in Review 2022. Gout Urate Cryst. Depos. Dis.2023, 1(3), 115-121; https://doi.org/10.3390/gucdd1030011– 23 Jun 2023.
  Stamp, L.K., Farquhar, H., Pisaniello, H.L. , Vargas- Santos, A.B.,
  Fisher. M. , Mount, D.B., Choi, H.K., Terkeltaub. R., Hill, C.L., Gaffo, A.L.  (2021). Management of gout in chronic kidney disease: a G-CAN Consensus Statement on the research priorities. Nat Rev Rheumatol. https://doi.org/10.1038/s41584-021-00657-4.
• Bursill, D., Taylor, W.J., Terkeltaub, R., Dalbeth, N.  (2018). The nomenclature of the basic disease elements of gout: A content analysis of contemporary medical journals. Semin Arthritis Rheum.  Dec; 48(3):456-461. doi: 10.1016/j.semarthrit.2018.03.017.  Epub 2018 Mar 28. PMID: 29706241; PMCID: PMC7372969. 
• Bursill, D., Taylor, W.J., Terkeltaub, R., Kuwabara, M., Merriman, T.R., Grainger, R.,
  Pineda. C., Louthrenoo, W., Edwards, N.L., Andrés, M., Vargas-Santos, A.B., Roddy, .E, Pascart, T., Lin, C.T., Perez-Ruiz, F., Tedeschi, S.K., Kim, S.C., Harrold, L.R., McCarthy, G., Kumar, N., Chapman, P.T., Tausche, A.K., Vazquez-Mellado, J., Gutierrez, M., da Rocha Castelar-Pinheiro, G., Richette, P., Pascual, E., Fisher, M.C., Burgos-Vargas, R., Robinson, P.C., Singh, J.A., Jansen, T.L., Saag, K.G., Slot, O., Uhlig, T., Solomon, D.H., Keenan, R.T., Scire, C.A., Biernat-Kaluza, E., Dehlin, M., Nuki, G., Schlesinger, N., Janssen, M., Stamp, L.K., Sivera, F., Reginato, A.M., Jacobsson, L., Lioté, F., Ea, H.K., Rosenthal, A., Bardin, T., Choi, H.K., Hershfield, M.S., Czegley, C., Choi, S.J., Dalbeth, N. (2019) Gout, Hyperuricemia, and Crystal-Associated Disease Network consensus statement regarding labels and definitions for disease elements in gout. Arthritis Care Res (Hoboken), 71(3):427-434. doi: 10.1002/acr.23607. PMID: 29799677; PMCID: PMC6252290.
• Bursill D., Taylor, W.J., Terkeltaub, R., Abhishek, A., So, A.K., Vargas-Santos, A.B.,
  Gaffo, A.L., Rosenthal, A., Tausche, A.K., Reginato, A., Manger, B., Sciré, C., Pineda, C., van Durme, C., Lin, C.T., Yin, C., Albert, D.A., Biernat-Kaluza, E., Roddy, E., Pascual, E., Becce, F., Perez-Ruiz, F., Sivera, F., Lioté, F., Schett, G., Nuki, G., Filippou, G., McCarthy, G., da Rocha Castelar Pinheir, G., Ea, H.K., De Almeida Tupinambá, H., Yamanaka, H., Choi, H.K., Mackay, J., ODell, J.R., Vázquez Mellado, J., Singh, J.A., Fitzgerald, J.D., Jacobsson, L.T.H., Joosten, L., Harrold, L.R., Stamp, L., Andrés M., Gutierrez, M., Kuwabara, M., Dehlin, M., Janssen, M., Doherty, M., Hershfield, M.S., Pillinger, M., Edwards, N.L., Schlesinger, N., Kumar, N., Slot, O., Ottavian, S., Richette, P., MacMullan, P.A., Chapman, P.T., Lipsky, P.E., Robinson, P., Khanna, P.P., Gancheva, R.N., Grainger, R., Johnson, R.J., Te Kampe, R., Keenan, R.T., Tedeschi, S.K., Kim, S., Choi, S.J., Fields, T.R., Bardin, T., Uhlig, T., Jansen, T., Merriman, T., Pascart, T., Neogi, T., Klück, V., Louthrenoo, W., Dalbeth, N. (2019) Gout, Hyperuricaemia and Crystal-Associated Disease Network (G-CAN) consensus statement regarding labels and definitions of disease states of gout. Ann Rheum Dis., 78(11):1592-1600. doi: 10.1136/annrheumdis-2019-215933. Epub 2019 Sep 9. PMID: 31501138; PMCID:PMC7288724.
• Murdoch, R.,  Barry, M.J., Choi , H.K., Hernandez , D. , Johnsen, B. , Labrador, M., Reid, S., Singh, J. A. , Terkeltaub, R. , Mellado, J., Dalbeth, N. (2021) Hyperuricaemia and Crystal-Associated Disease Network (G-CAN) common language definition of gout. RMD Open, 7:e001623. doi: 10.1136/rmdopen-2021-001623.
• Derksen, C.,  Murdoch, R., Keith, J., Petrie, K.J., Dalbeth, N. (2021) An apple pie a day does not keep the doctor away: Fictional depictions of gout in contemporary film and television. BMC Rheumatology, 5:4. https://doi.org/10.1186/s41927-020-00174-z.
• Farquhar, H. Vargas-Santos, A. B., Pisaniello, H. L., Fisher, M., Hill, C., Gaffo, A.L., Stamp, L.K. (2021). Efficacy and safety of urate-lowering therapy in people with Kidney Impairment: A G-CAN Initiated Literature Review. Rheumatology Advances in Practice, 0:1–13; doi:10.1093/rap/rkaa073. Advance Access Publication 4 January 2021. 
• Stamp, L.K., Taylor, W., and Gaffo, A. (2020). Variability in urate-lowering therapy prescribing: A gout, hyperuricemia and crystal-associated disease network (G-CAN) physician survey. The Journal of Rheumatology,  jrheum.200347; doi.org/10.3899/jrheum.200347. 
• Bursill, D., Taylor, W.J., Terkeltaub, R., Abhishek, A.,  So, A.K., Vargas-Santos, A.B., Gaffo, A.L., Rosenthal, A., Tausche, A., Reginato, A., Manger, B., Sciré, C., Pineda, C., van Durme, C., Lin, C.,  Yin, C.,  Albert, D. A., Biernat-Kaluza, E., Roddy, E., Pascual, E., Becce, F., Perez-Ruiz,F., Sivera, F., Lioté, F.,  Schett, G., Nuki, G., Filippou, G., McCarthy, G., da Rocha Castelar Pinheiro, G., Ea, H.K., De Almeida Tupinambá, H., Yamanaka, H., Choi, H.K., Mackay, J., ODell, J.R., Vázquez Mellado, J., Singh, J.A., Fitzgerald, J.D., Jacobsson, L.T.H.,  Joosten, L., Harrold, L.R., Stamp, L.K., Andrés, M., Gutierrez, M., Kuwabara, M., Dehlin, M., Janssen, M.,  Doherty, M., Hershfield, M.S.,  Pillinger, M., Edwards, N.L., Schlesinger, N., Kumar, N., Slot, O., Ottaviani, S., Richette, P., MacMullan, P.A., Chapman, P.T.,  Lipsky, P.E., Robinson, P., Khanna, P.P., Gancheva, R.N., Grainger, R., Johnson, R.J., Te Kampe, R., Keenan, R.T., Tedeschi, S.K., Kim, S., Choi, S.J., Fields, T.R., Bardin, T., Uhlig, T.,  Jansen, T., Merriman, T., Pascart, T., Neogi, T.,  Klück, V., Louthrenoo, W., Dalbeth, N. (2019) Gout, Hyperuricemia, and Crystal-Associated Disease Network consensus statement regarding labels and definitions for disease elements in gout. Ann Rheum Dis. Nov;78(11):1592-1600. doi: 10.1136/annrheumdis-2019-215933. Epub 2019 Sep 9.
• Abhishek, A., Neogi, T., Choi, H.K., Doherty, M.K., Rosenthal, A. K., Terkeltaub, R. (2018). Review: Unmet needs and the path forward in joint disease associated with calcium pyrophosphate crystal deposition. Arthritis Rheumatol. Aug;70(8):1182-1191. doi: 10.1002/art.40517. Epub 2018 Jun 14.
• Dalbeth, N., Bardin, T., Doherty, M., Lioté, F., Richette, P., Saag, K.G., So, A.K., Stamp, L.K., Choi, H.K., Terkeltaub, R. (2017) Discordant American College of Physicians and international rheumatology guidelines for gout management: consensus statement of the Gout, Hyperuricemia and Crystal-Associated Disease Network (G-CAN). Nat Rev Rheumatol. 2017 Sep;13(9):561-568. doi: 10.1038/nrrheum.2017.126. Epub 2017 Aug 10.

2020 Consensus Documents

• 2020 Disease Elements
• 2020 Disease States Consensus