Publications

Gout, Urate and Crystal Deposition Disease journal

G-CAN Journal

Gout, Urate and Crystal Deposition Disease is the first journal focused exclusively on the broad field of gout, urate and hyperuricemia biology and genomics, and crystal deposition disease. This is an online-only, entirely open access journal of G-CAN as a society. All issues are available online at mdpi.com/journal/gucdd.

Jump to: 2026 · 2025 · 2024 · 2023 · Consensus papers

Gout, Urate and Crystal Deposition Disease

2026 4 papers

Anouchka Jasmine Lewis. Bridging the Diagnostic Gap in Calcium Pyrophosphate Deposition Disease and Basic Calcium Phosphate Arthropathies: Translating Research Advances into Routine Clinical Care. Gout Urate Cryst Depos Dis. 2026;4(2):12.
Christèle Asmar, Nelly Ziadé and Jean W. Liew. Overlap of Gout and Calcium Pyrophosphate Deposition with Osteoarthritis, Rheumatoid Arthritis, and Psoriatic Arthritis: Epidemiology, Clinical-Radiological Profiles, Outcomes, and Management. Gout Urate Cryst Depos Dis. 2026;4(2):11.
Allyson Covello, Salim Zenkhri, Cheongeun Oh, Michael H. Pillinger, Michael Toprover and Fabio Becce. Prevalence and Severity of Spinal Osteoarthritis in Gout Patients Versus Non-Gout Controls. Gout Urate Cryst Depos Dis. 2026;4(2):10.
Viola Klück, Nienke Ponsteen, Sander I. van Leuven and Leo A. B. Joosten. Hyperuricemia Beyond Gout: The Unknown Culprit in Rheumatic and Musculoskeletal Diseases. Gout Urate Cryst Depos Dis. 2026;4(2):9.

2025 22 papers

Vicky Tai, Charlotte Jauffret, Nicola Dalbeth and Tristan Pascart. The Fast-Evolving Landscape of Treatments for Calcium Pyrophosphate Deposition Disease. Gout Urate Cryst Depos Dis. 2025;3(4):22.
Elena Sansano-Muñoz, María-del-Carmen López-González, Cristina Rodríguez-Alvear, Irene Calabuig, Agustín Martínez-Sanchis, Carlos Rodríguez-Navarro, Eliseo Pascual and Mariano Andrés. Length of Monosodium Urate Crystals in Synovial Fluid Based on Ultrasound Articular Deposits: Advancements in Crystallization Process. Gout Urate Cryst Depos Dis. 2025;3(4):21.
Sumanth Chandrupatla, Nicholas Sumpter, Riku Takei, Tony R. Merriman and Jasvinder Singh. Testing for Causal Association Between Serum Urate, Gout, and Prostatic Cancer in European Males. Gout Urate Cryst Depos Dis. 2025;3(4):20.
Michael Toprover and Michael H. Pillinger. Controversies in Urate-Lowering Therapy for Gout: A Comprehensive Review. Gout Urate Cryst Depos Dis. 2025;3(4):19.
John D. FitzGerald, Rita Kachru, Chen Xie and Veena K. Ranganath. Use of Rituximab to Attempt Recapture of Immune Tolerance to Pegloticase. Gout Urate Cryst Depos Dis. 2025;3(3):18.
Robert Terkeltaub. Follow the Molecule from Crystal Arthropathy to Comorbidities: The 2024 G-CAN Gold Medal Award Awardee Lecture. Gout Urate Cryst Depos Dis. 2025;3(3):17.
Yuqi Wang, Jinshuo Han, Jasmin Knopf, Lingjiang Zhu, Yi Zhao, Lei Liu and Martin Herrmann. NET Formation Drives Tophaceous Gout. Gout Urate Cryst Depos Dis. 2025;3(3):16.
Rocio Paz Gonzalez and Monica Guma. Year in Review: Advances in Research in Gout Pathophysiology in 2024. Gout Urate Cryst Depos Dis. 2025;3(3):15.
M. Leonor Cancela, Ahmed Alouane, Pietro M. Bertelli, Antonio Camacho, Robbe Derudder, Antonella Forlino, Matthew P. Harris, Marta Jacinto, Imre Lengyel, Wolfgang Link, Monzur Murshed, Andreas Pasch, Arun-Kumar Kaliya-Perumal, Daniela Quaglino, Zihan Qin, Yves Sabbagh, Elena Seminari, Marcos M. Villar, Christoph Winkler and Olivier M. Vanakker. 2024 Annual Meeting of the International Network on Ectopic Calcification (INTEC)—Abstract Proceedings. Gout Urate Cryst Depos Dis. 2025;3(3):14.
Ana Beatriz Vargas-Santos, Christine E. Peloquin and Tuhina Neogi. Effect of Allopurinol Use on Kidney Function Among Patients with Gout and Chronic Kidney Disease. Gout Urate Cryst Depos Dis. 2025;3(3):13.
Kanon Jatuworapruk, Jassdakorn Suaypring, Natrawee Ngamprasertsith and Nattawat Watcharajittanont. Persistence of Monosodium Urate Crystals and Calcium Pyrophosphate Crystals in Synovial Fluid Samples After Two Weeks of Storage at 4 °C and −20 °C: A Longitudinal Analysis. Gout Urate Cryst Depos Dis. 2025;3(3):12.
Gabriela Sandoval-Plata, Kevin Morgan Morgan, Michael Doherty and Abhishek Abhishek. Inter-Critical Gout, Not Hyperuricemia or Asymptomatic Urate Crystal Deposition, Is Associated with Systemic Inflammation. Gout Urate Cryst Depos Dis. 2025;3(3):11.
Gout and Hyperuricemia and Crystal–Associated Disease Network. Gout, Hyperuricemia and Crystal-Associated Disease Network (G-CAN) Conference 2024: Early-Career Investigators’ Abstracts. Gout Urate Cryst Depos Dis. 2025;3(2):10.
Mai Sekine and Kimiyoshi Ichida. Metabolic Impact of XOR Inhibitors Use and Discontinuation. Gout Urate Cryst Depos Dis. 2025;3(2):9.
Fiorella Rosas-Chavez and Tony R. Merriman. Mendelian Randomization Studies: A Metric for Quality Evaluation. Gout Urate Cryst Depos Dis. 2025;3(2):8.
Maddalena Zangari, Roberto Luisetto, Roberto Pilot, Paola Contessa, Raffaella Signorini, Stefano Masiero and Anna Scan. Comparison of Pathophysiological Mechanisms Among Crystal-Induced Arthropathies. Gout Urate Cryst Depos Dis. 2025;3(2):7.
Riku Takei, Nicholas A. Sumpter, Megan P. Leask and Tony R. Merriman. Colocalization Analysis Reveals Shared Genetic Loci Contributing to Gout and Metabolite Levels. Gout Urate Cryst Depos Dis. 2025;3(2):6.
Natalie Anumolu, Ann Rosenthal, Katherine Sherman and Shikha Singla. Higher Rates of Psoriatic Arthritis in Patients with Calcium Pyrophosphate Deposition Disease than in Controls: A Retrospective Cohort Study. Gout Urate Cryst Depos Dis. 2025;3(2):5.
Renaud Felten, Laura Widawski, Pierre-Marie Duret, Lionel Spielmann and Laurrent Messer. Convergence of Psoriatic Arthritis and Hyperuricemia: A Review of Emerging Data from This New Concept Called “Psout”. Gout Urate Cryst Depos Dis. 2025;3(1):4.
Anusha Moses, Martijn Oude Voshaar, Mart van de Laar and Tim L. Th. Jansen. Treat to Target in Gout Management: A Critical Reappraisal of Current Strategies. Gout Urate Cryst Depos Dis. 2025;3(1):3.
Pascal Richette, Marcel Flendrie, Leo A. B. Joosten and Noortje van Herwaarden. Can Urate Lowering Therapy Be Stopped in Gout? Rationale and Design of Two Large Randomised Trials. Gout Urate Cryst Depos Dis. 2025;3(1):2.
Aichang Ji, Zibin Tian, Yongyong Shi, Riku Takei, Shun-Jen Chang, Ronald M. L. Yip, Huiyong Yin and Changgui Li. Gout in China. Gout Urate Cryst Depos Dis. 2025;3(1):1.

2024 20 papers

Greg Challener and Chio Yokose. Year in Review 2023: Gout Clinical Research. Gout Urate Cryst Depos Dis. 2024;2(4):354–369.
Ira Khanna, Venkatesh Mani, Renata Pyzik, Audrey Kaufman, Weiwei Chi, Emilia Bagiella, Philip Robson and Yousaf Ali. Assessing Changes in Vascular Inflammation and Urate Deposition in the Vasculature of Gout Patients After Administration of Pegloticase Using Positron Emission Tomography and Dual-Energy Computed Tomography—A Pilot Study. Gout Urate Cryst Depos Dis. 2024;2(4):339–353.
Ancuta R. Straton, Brenda Kischkel, Tania O. Crișan and Leo A. B. Joosten. Epigenomic Reprogramming in Gout. Gout Urate Cryst Depos Dis. 2024;2(4):325–338.
John D. FitzGerald, Chesca Barrios, Tairan Liu, Ann Rosenthal, Geraldine M. McCarthy, Lillian Chen, Bijie Bai, Guangdong Ma and Aydogan Ozcan. A Novel Polarized Light Microscope for the Examination of Birefringent Crystals in Synovial Fluid. Gout Urate Cryst Depos Dis. 2024;2(4):315–324.
Sonia Nasi, Mario Romani and Nathalie Busso. Age-Associated Calcification: Insights from Murine Models. Gout Urate Cryst Depos Dis. 2024;2(3):236–251.
Gout, Hyperuricemia and Crystal-Associated Disease Network. Gout, Hyperuricemia and Crystal-Associated Disease Network (G-CAN) Conference 2023: Early-Career Investigators’ Abstracts. Gout Urate Cryst Depos Dis. 2024;2(2):173–205.
Ava M. Zapf and Owen M. Woodward. SGLT2 Inhibitors and Uric Acid Homeostasis. Gout Urate Cryst Depos Dis. 2024;2(2):157–172.
Panagiota Drivelegka, Lennart TH Jacobsson and Mats Dehlin. Gout and Gout-Related Comorbidities: Insight and Limitations from Population-Based Registers in Sweden. Gout Urate Cryst Depos Dis. 2024;2(2):144–156.
Medeea Badii, Orsolya I. Gaal, Ioana Hotea, Valentin Nica, Andreea M. Mirea, Dragoş Mărginean, HINT Consortium, Cristina Pamfil, Simona Rednic, Radu A. Popp, Tania O. Crişan and Leo A. B. Joosten. Sex-Specific Differences in Cytokine Production Capacity in Patients with Gout Compared to Controls. Gout Urate Cryst Depos Dis. 2024;2(2):133–143.
Raewyn C. Poulsen and Nicola Dalbeth. Circadian Rhythms in NLRP3 Inflammasome Regulation: Possible Implications for the Nighttime Risk of Gout Flares. Gout Urate Cryst Depos Dis. 2024;2(2):108–132.
Augustin Latourte, Hang-Korng Ea and Pascal Richette. Calcium Pyrophosphate and Basic Calcium Phosphate Crystal Arthritis: 2023 in Review. Gout Urate Cryst Depos Dis. 2024;2(2):101–107.
Emilio Filippucci, Edoardo Cipolletta, Silvia Sirotti and Georgios Filippou. Optimising the Use of Ultrasound in Gout: A Review from the Ground Up. Gout Urate Cryst Depos Dis. 2024;2(2):86–100.
Leonard Stern, Richard J. Johnson, Payam Shakouri, Amod Athavale, Lissa Padnick-Silver, Brian LaMoreaux, Brad A. Marder and Sreedhar Mandayam. Prevalence and Influence of Gout in Patients with Advanced Chronic Kidney Disease: Findings of a Large Retrospective Chart Review. Gout Urate Cryst Depos Dis. 2024;2(1):77–85.
Lisa K. Stamp, Robin Christensen and Melanie B. Morillon. Serum Urate as a Surrogate Outcome for Gout Flares: Where Do We Stand Today?. Gout Urate Cryst Depos Dis. 2024;2(1):70–76.
Frédéric Lioté, Fernando Perez-Ruiz, Hang-Korng Ea, Tony Merriman, Tristan Pascart and Alexander So. 14th European Crystal Network (ECN) Workshop—Abstract Proceedings. Gout Urate Cryst Depos Dis. 2024;2(1):60–69.
Sara K. Tedeschi. A New Era for Calcium Pyrophosphate Deposition Disease Research: The First-Ever Calcium Pyrophosphate Deposition Disease Classification Criteria and Considerations for Measuring Outcomes in Calcium Pyrophosphate Deposition Disease. Gout Urate Cryst Depos Dis. 2024;2(1):52–59.
Tom Niessink, Matthijs Janssen, Tim L. Jansen and Cees Otto. The Prevalence of Titanium Dioxide Particles in Synovial Fluid Samples Drops after European Union Ban. Gout Urate Cryst Depos Dis. 2024;2(1):45–51.
Sébastien Ottaviani. Imaging Follow-Up of MSU Crystal Depletion. Gout Urate Cryst Depos Dis. 2024;2(1):34–44.
Georgios Filippou, Silvia Sirotti, Edoardo Cipolletta and Emilio Filippucci. Optimizing the Use of Ultrasound in Calcium Pyrophosphate Deposition (CPPD): A Review from the Ground Up. Gout Urate Cryst Depos Dis. 2024;2(1):17–33.
Jennifer Lee, Nicholas Sumpter, Tony R. Merriman, Ru Liu-Bryan and Robert Terkeltaub. The Evolving Landscape of Gout in the Female: A Narrative Review. Gout Urate Cryst Depos Dis. 2024;2(1):1–16.

2023 5 papers

Geraldine Mary McCarthy. Calcium Pyrophosphate and Basic Calcium Phosphate Deposition Diseases: The Year in Review 2022. Gout Urate Cryst Depos Dis. 2023;1(4):234–242.
Nellissa Y. Ling, Siân E. Halcrow and Hallie R. Buckley. Gout in Paleopathology: A Review with Some Etiological Considerations. Gout Urate Cryst Depos Dis. 2023;1(4):217–233.
T. Pascart, J. Budzik. Does Monosodium Urate Crystal Vascular Deposition Exist? Review of the Evidence. Gout Urate Cryst Depos Dis. 2023;1(3):208–216.
R. Liu-Bryan, T. Guo, J. Lee, R. Terkeltaub. Atherogenic Activation of Human Vascular Smooth Muscle Cells by Monosodium Urate Crystals. Gout Urate Cryst Depos Dis. 2023;1(3):192–207.
Gout, Hyperuricemia and Crystal-Associated Disease Network. Gout, Hyperuricemia and Crystal-Associated Disease Network (G-CAN) Conference 2022: Early-Career Investigators’ Abstracts. Gout Urate Cryst Depos Dis. 2023;1(3):167–191.

G-CAN consensus and position papers

Consensus and position papers 9 papers

Farquhar H, Vargas-Santos AB, Pisaniello HL, et al. Efficacy and safety of urate-lowering therapy in people with kidney impairment: a G-CAN-initiated literature review. Rheumatol Adv Pract. 2021:rkaa073.
Derksen C, Murdoch R, Keith J, Petrie KJ, Dalbeth N. An apple pie a day does not keep the doctor away: fictional depictions of gout in contemporary film and television. BMC Rheumatol. 2021;5:4.
Murdoch R, Barry MJ, Choi HK, et al. Gout, Hyperuricaemia and Crystal-Associated Disease Network (G-CAN) common language definition of gout. RMD Open. 2021;7:e001623.
Stamp LK, Taylor W, Gaffo A. Variability in urate-lowering therapy prescribing: a Gout, Hyperuricemia and Crystal-Associated Disease Network (G-CAN) physician survey. J Rheumatol. 2020:jrheum.200347.
Bursill D, Taylor WJ, Terkeltaub R, et al. Gout, Hyperuricaemia and Crystal-Associated Disease Network (G-CAN) consensus statement regarding labels and definitions of disease states of gout. Ann Rheum Dis. 2019;78(11):1592–1600.
Bursill D, Taylor WJ, Terkeltaub R, et al. Gout, Hyperuricemia, and Crystal-Associated Disease Network consensus statement regarding labels and definitions for disease elements in gout. Arthritis Care Res (Hoboken). 2019;71(3):427–434.
Abhishek A, Neogi T, Choi HK, Doherty M, Rosenthal AK, Terkeltaub R. Review: unmet needs and the path forward in joint disease associated with calcium pyrophosphate crystal deposition. Arthritis Rheumatol. 2018;70(8):1182–1191.
Bursill D, Taylor WJ, Terkeltaub R, Dalbeth N. The nomenclature of the basic disease elements of gout: a content analysis of contemporary medical journals. Semin Arthritis Rheum. 2018;48(3):456–461.
Dalbeth N, Bardin T, Doherty M, et al. Discordant American College of Physicians and international rheumatology guidelines for gout management: consensus statement of the Gout, Hyperuricemia and Crystal-Associated Disease Network (G-CAN). Nat Rev Rheumatol. 2017;13(9):561–568.

2020 consensus documents 2 papers